Overcoming early inflammation after transplantation using cell protective therapy

An initial study using 'Mirococept' planted in donor organs is about to enter a Phase II efficacy study in renal transplantation. This work is being led by Professor Steven Sacks, Dr Richard Smith and Mr Martin Drage. Additionally with theme lead Professor Anthony Dorling, coagulation pathways are being studied for potential therapeutic benefit and also to discover possible interactions between the complement cascade and clotting cascades.

Working with Professor Stephanie Amiel, Professor Anil Dhawan and Dr Guo Cai Huang the Centre will investigate the possible uses of cell protection in islet and hepatocyte transplantation. The early loss of cells from these transplants may be due to a complement or coagulation response.

In addition this research theme will investigate new molecular targets to introduce more effective, less toxic therapies. This will include work with Dr Wuding Zhou to target certain complement receptors which may help our understanding of how the immune system discriminates self and non self.

Work with Professor Prokar Dasgupta will investigate the use of robotic approaches in prostate cancer to allow precise intra-lesion localisation of therapy.

This link of therapeutic needs to detailed understanding of mechanism and to skills in protein engineering highlight the value of this Centre.

Complement: Professor Steven Sacks, Dr Wuding Zhou
Coagulation: Professor Anthony Dorling
Stress Pathways: Professor Adrian Hayday
Protein Therapeutics: Dr Richard Smith
Kidney/Pancreas: Mr Martin Drage
Islet/Hepatocyte: Professor Stephanie Amiel, Professor Anil Dhawan
Surgical Innovation: Professor Prokar Dasgupta