The MRC Centre for Transplantation aims to translate basic discovery into new therapeutic, diagnostic and prognostic applications. The MRC Centre spans several programmes of research, including innate immunity (Hayday), complement (Sacks), coagulation (Dorling), immune biology (Noelle) immune regulation (Lechler; Lombardi; Lord), humanised models (Nestle), stem cell biology (Sharpe), genetics (Solomon) and imaging (Razavi). Its science base cuts across liver, kidney, pancreas, bone marrow, islets, hepatocyte and stem cell transplantation, in what is one of the largest patient groups in Europe.
The Centre incorporates a training theme in research ethics and legislation via links with the Centre of Medical Law and Ethics at KCL. The MRC Centre is closely linked with the Transplant theme of the NIHR Comprehensive Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust.
The award to King's of a new MRC Centre for Transplantation was announced in March 2007. This was one of five such prestigious research centres awarded to King's - more than any other University.
The main administrative site for the Centre is housed at Guy's Campus of King's College London. This central office houses the Centre Director, Professor Steve Sacks, and the administrative and support team led by Centre Manager, Dr Elena Bedisti.
The Themes (and Leads), which align science and translational priorities of the Centre are:
1. Overcoming early inflammation after transplantation using cytoprotective therapy:
Complement: Professor Steven Sacks, Dr Wuding Zhou
Coagulation: Professor Anthony Dorling
Stress Pathways: Professor Adrian Hayday
Protein Therapeutics: Dr Richard Smith
Kidney/Pancreas: Mr Martin Drage
Islet/Hepatocyte: Professor Stephanie Amiel, Professor Anil Dhawan
Surgical Innovation: Professor Prokar Dasgupta
2. Networks that regulate tolerance and promote long term graft acceptance:
Immune Intervention: Professor Randolph Noelle, Dr Wilson Wong
Complement: Dr Claudia Kemper
T cell therapy: Professor Robert Lechler, Professor Giovanna Lombardi
Humanised mice: Professor Frank Nestle
Tooth replacement: Professor Paul Sharpe
Haematopoietic stem cell: Professor Ghulam Mufti
Kidney/Pancreas: Mr Nizam Mamode
3. Immune prediction and monitoring as a guide to patient care:
T cell differentiation: Professor Graham Lord, Dr Maria Hernandez-Fuentes
Genomics: Professor Ellen Solomon, Professor David Grimwade, Dr Michael Weale
Immune Monitoring: Professor Terrence Strom
Diabetic Immunology: Professor Mark Peakman, Dr Tim Tree
Liver: Professor Alberto Sanchez-Fueyo, Mr Nigel Heaton
4. Investigating the inflammatory and immune response by external imaging:
Immune imaging: Professor Reza Razavi, Dr Gregory Mullen
Structural biology: Professor James McDonnell
The Centre's training programme provides an experience of the distinctive elements of our research as well as the fundamental aspects of immunology. Trainees completing the programme will therefore have knowledge of how transplant research informs science, technology and clinical medicine and will have developed a keen sense of the regulatory, ethical and societal dimensions of the research. The Centre's education and training leads are:
Life science students: Dr Stipo Jurcevic
Medical Law & Ethics: Professor Genevra Richardson
Ethics: Dr Antonia Cronin
The Centre incorporates a training theme in research ethics and legislation via links with the Centre of Medical Law and Ethics at KCL. The MRC Centre is closely linked with the Transplant theme of the NIHR Comprehensive Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust.
OUR MISSION
Improve the health of transplant recipients by high quality research on the inflammatory and immune responses
Facilitate the application of biological technologies - genetics, therapeutics, imaging and stem cells
Sustain progress though recruitment and training
Promote dialogue with the public about transplant research
Who we work with
The award to King's of a new MRC Centre for Transplantation was announced in March 2007. This was one of five such prestigious research centres awarded to King's - more than any other University.
The main administrative site for the Centre is housed at Guy's Campus of King's College London. This central office houses the Centre Director, Professor Steve Sacks, and the administrative and support team led by Centre Manager, Dr Elena Bedisti.
The Themes (and Leads), which align science and translational priorities of the Centre are:
1. Overcoming early inflammation after transplantation using cytoprotective therapy:
Complement: Professor Steven Sacks, Dr Wuding Zhou
Coagulation: Professor Anthony Dorling
Stress Pathways: Professor Adrian Hayday
Protein Therapeutics: Dr Richard Smith
Kidney/Pancreas: Mr Martin Drage
Islet/Hepatocyte: Professor Stephanie Amiel, Professor Anil Dhawan
Surgical Innovation: Professor Prokar Dasgupta
2. Networks that regulate tolerance and promote long term graft acceptance:
Immune Intervention: Professor Randolph Noelle, Dr Wilson Wong
Complement: Dr Claudia Kemper
T cell therapy: Professor Robert Lechler, Professor Giovanna Lombardi
Humanised mice: Professor Frank Nestle
Tooth replacement: Professor Paul Sharpe
Haematopoietic stem cell: Professor Ghulam Mufti
Kidney/Pancreas: Mr Nizam Mamode
3. Immune prediction and monitoring as a guide to patient care:
T cell differentiation: Professor Graham Lord, Dr Maria Hernandez-Fuentes
Genomics: Professor Ellen Solomon, Professor David Grimwade, Dr Michael Weale
Immune Monitoring: Professor Terrence Strom
Diabetic Immunology: Professor Mark Peakman, Dr Tim Tree
Liver: Professor Alberto Sanchez-Fueyo, Mr Nigel Heaton
4. Investigating the inflammatory and immune response by external imaging:
Immune imaging: Professor Reza Razavi, Dr Gregory Mullen
Structural biology: Professor James McDonnell
The Centre's training programme provides an experience of the distinctive elements of our research as well as the fundamental aspects of immunology. Trainees completing the programme will therefore have knowledge of how transplant research informs science, technology and clinical medicine and will have developed a keen sense of the regulatory, ethical and societal dimensions of the research. The Centre's education and training leads are:
Life science students: Dr Stipo Jurcevic
Medical Law & Ethics: Professor Genevra Richardson
Ethics: Dr Antonia Cronin
